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. 2011 Mar 4;2(5):348–352. doi: 10.1021/ml100287y

Scheme 1. Syntheses of 3−6 from 1.

Scheme 1

Reagents: (a) for 3, NFSi, HCOOH; (b) for 4, NCS, AcOH; (c) for 5, NBS, AcOH; (d) for 6, NIS, AcOH; (e) SnCl4, Cl2CHOMe, CH2Cl2; (f) 80% MMPP, MeOH; (g) NaClO2, NaH2PO4, 2-methyl-2-butene, t-BuOH/H2O; (h) DPPA, Et3N, THF/H2O; (i) CAN, TFAA, CH2Cl2. Abbreviations: NFSi, N-fluorodisulfoneimide; NCS, N-chlorosuccinimide; NBS, N-bromosuccinimide; NIS, N-iodosuccinimide; MMPP, magnesium bis(monoperoxyphthalate); DPPA, diphenylphosphoryl azide; CAN, cerium(IV) ammonium nitrate; TFAA, trifluoroacetic anhydride.