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. 2010 Nov 2;2(1):58–62. doi: 10.1021/ml100215b

Figure 2.

Figure 2

(A) Expression of fear-potentiated and baseline startle response (0.3−3 mg/kg compound 15i). Mean startle magnitudes and SEMs of startle stimulus alone and CS-startle stimulus trials, respectively, as well as the difference. Multifactorial ANOVA: interaction treatment × trial type: F3,36 = 7.49, p < 0.001, p = 0.001; **p < 0.01 (Dunnett post hoc test vs 0 mg/kg). (B) Brain concentration (mean ± SEM) of compound 15i in the different treatment groups as well as the mean percent startle difference (±SEM). Compound 15i brain levels are negatively correlated with the expression of fear-potentiated startle. For experimental details see the Supporting Information.