Table 3. Pharmacokinetic Parameters^a of 15i^b and 1^c.

	15i	1
plasmaCL (mL/min/kg)	15	37
MRT (h)	2.2	0.9
t1/2 (h)	1.9	0.9
Tmax (h)	0.5	0.25
Cmaxd (pmol/mL/μmol/kg)	60	41
AUCpod (pmol h/mL/μmol/kg)	449	241
F (%)	41	54
brain/plasma-AUCpo ratio	1.67	1.36

^an = 3 Sprague−Dawley rats/group.

^b3.6 μmol/kg po, 2.4 μmol/kg iv.

^c30 μmol/kg po, 10 μmol/kg iv.

^dDose-normalized value.