Table 3. Pharmacokinetic Properties of 3.

parameter	rat	mouse	dog
IV dose (mg/kg)	4.8	2	13.8
n	3	3	4
T1/2 (h)	1.9	2.6	1.5
Vss (L/kg)	3.9	2.2	2.3
AUC (μg·h/mL)	1.26	1.54	6.12
Cl (mL/min/kg)	63	21	39
PO dose (mg/kg)	43	40	33
n	3	3	4
T1/2 (h)	4.5	4.5	4.5
Cmax (μg/mL)	0.89	7.85	1.37
AUC (μg·h/mL)	6.3	26.96	4.34
F (%)	56	87	69