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. 2011 Jan 13;2(4):280–284. doi: 10.1021/ml100276b

Figure 1.

Figure 1

(A) Superimposition of Bcl-xL with the Bim (orange), Bad(cyan), and Bec1 (blue) BH3 peptides. (B) Structural alignment between the ligand-free Bcl-xL(yellow) and Bcl-xL with the Bim peptide(green). H1-4 and p1 residues of the Bim peptide are shown in orange. Conformational changes of the α3 helix in Bcl-xL when binding to (C) Bim (green), (D) Bad (cyan), and (E) Bec1 (blue) peptide. The reference structure of ligand-free Bcl-xL is shown in yellow. The PyMOL program (www.pymol.org) was used to view the protein models and prepare the graphics.