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(A) Chemical structure of THF. (B) Superposition of the four dNTP/THF-containing structures (dATP/THF, red; dCTP/THF, blue; dGTP/THF, orange; dTTP/THF, gray). The PB’s ddC/dG is shown as a space-filling model. (C) Base stacking of an incoming dCTP with ddG/dC. (D) Base stacking of an incoming dCTP with ddA/dT. (E) Base stacking of an incoming dATP with ddC/dG. (F) Base stacking of an incoming dATP with ddA/dT.
