Table 2. In Vivo PTH Secretion Activity of the Selected Compounds in Rats.
| PTH secretiona | |||
|---|---|---|---|
| compd | 1 mg/kg | 3 mg/kg | 10 mg/kg |
| 8 | NT | + | NT |
| 12 | − | + | ++ |
| 13 | + | ++ | NT |
| 14 | − | ++ | NT |
| 15 | ++ | ++ | ++ |
a
Increases of serum PTH 1−34 levels (Δ) were compared with levels observed in control rats treated with vehicle. The peak levels, measured at 15 or 30 min after oral administration of the compounds in rats (n = 5), were compared with the levels observed in animals treated with compound 1 (30 mg/kg, po, ∼2−4-fold increases). ++, >80% of compound 1; +, 50−80% of compound 1; −, <50% of compound 1; NT, not tested.