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. 2011 Mar 11;2(5):402–406. doi: 10.1021/ml200045s

Table 2. SAR of Tetrazole Containing GSNOR Inhibitors.

compd R1 R3 R4 n GSNOR IC50 (nM)
22 OMe Me CONH2 1 1530
23 OMe Me CONH2 0 2910
24 Br Me CONH2 1 190
25 Br Me CONH2 0 560
26 Br H OH 1 450
27 Br H OH 0 4350
28 1H-imidazol-1-yl H OH 1 300
29 1H-imidazol-1-yl H OH 0 18