Table 2. Binding Affinity of Tritium-Labeled 14b, 16b, and 17b versus Human AD Brain Homogenates from Three Different Donors.
| compd | Kd (nM)a | Bmax (nM) | Bmax/Kd | NDBb |
|---|---|---|---|---|
| [3H3]14b | 4.5 ± 0.6 | 2088 ± 231 | 464 ± 80 | 50% |
| [3H3]16b | 6.4 ± 0.9 | 1454 ± 140 | 232 ± 40 | 50% |
| [3H3]17b | 9.6 ± 0.3 | 1100 ± 290 | 117 ± 34 | 35% |
a
Values are means of three experiments using AD brain homogenates from different donors.
b
Nondisplaceable binding, estimated as the amount of binding observed at the Kd in the presence of 2 μM unlabeled compound