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. 2011 Sep 27;2(12):896–900. doi: 10.1021/ml200197e

Figure 4.

Figure 4

(a) Antagonist 13e (yellow) modeled into the ligand-binding pocket of RXRa (PDB code: 2P1V)32 and superposed onto the agonist 4. The white stick molecule is a RXR-partial agonist UVI3002, which binds in the ligand-binding domain of RXRα (2P1V). The asterisk indicates a steric clash between the side chain of 13e and Leu451 in helix 12 (H12). (b) Antagonist 13e (yellow) modeled into the ligand-binding pocket of RXRα (PDB code: 3A9E).33 The white stick molecule is RXR antagonist LG100754, which binds in the ligand-binding domain of RXRα (3A9E). (c) An enlarged view of the boxed region in b.