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. 2014 Mar 31;13(5):2679–2687. doi: 10.1021/pr500145n

Figure 5.

Figure 5

SCD1 mediates CYP1B1-induced obesity. (A) Western blot analysis of SCD1 in the liver of wild-type (+/+) and Cyp1b1-null (−/−) mice with SCD1 overexpression. (B) Body weight of wild-type (WT) and Cyp1b1-null mice after three Ad-Scd1 injections. (C) Serum levels of LPC 18:0 in Cyp1b1-null and wild-type mice with SCD1 overexpression. The concentrations of serum lysophosphatidylcholines were measured by triple quadrupole tandem mass spectrometry. Statistical analysis was performed using two-tailed Student’s t test (n = 5 in each group). *, P < 0.05 compared with Cyp1b1-null mice treated with Ad-ctr (Ad-ctr Cyp1b1-null).