. 2010 Nov 9;2(2):102–106. doi: 10.1021/ml100228m

Table 2. SAR of 6-Benzyl-Substituted Bicyclic Cores^a.

graphic file with name ml-2010-00228m_0004.jpg

compd	W	X	Y	Z	hS1P₁ RI EC₅₀ (μM) (% efficacy)	hS1P₃ Ca²⁺ EC₅₀ (μM) (% efficacy)
9	O	C	CH	C	0.013 (110)	0.679 (42)
10	O	C	N	C	0.094 (108)	0.542 (87)
11	N	C	S	C	0.042 (102)	1.21 (24)
12	N	C	CH	N	0.741 (110)	6.09 (50)
13	N	N	CH	C	1.81 (100)	2.71 (48)

Data represent an average of at least two determinations. Percent efficacy is reported as in Table 1.

Table 2. SAR of 6-Benzyl-Substituted Bicyclic Coresa.