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. 2010 Nov 9;2(2):102–106. doi: 10.1021/ml100228m

Table 4. Pharmacokinetic Parameters for 14.

species Cl (L/h/kg) Vss (L/kg) T1/2 (h) MRT (h) % F
rata 0.33 3.3 7.5 10 68
NHPb 0.50 1.6 35.2 3.3 23
a

Female Sprague−Dawley (iv: 2 mg/kg, DMSO, N = 3; po: 15 mg/kg, 20% captisol, pH 2, N = 3).

b

Male Cynomolgus (iv: 4 mg/kg, 20% captisol, pH 4, N = 3; po: 10 mg/kg, 20% captisol, 1% pluronic F68, 1% HPMC, pH 2, N = 3).