. 2011 Apr 18;2(7):538–543. doi: 10.1021/ml200070g

Table 2. Structures and KHK Inhibition Results for Analogues of 3 with Variation of R₂ and R₃.

graphic file with name ml-2011-00070g_0006.jpg

compd^a	N-R₂	N-R₃	IC₅₀ (nM)^b
2	NH-Me	piperazino	400
22	NH-Pr	piperazino	400
23	NH-hexyl	piperazino	1600
24	NH-(c-hexyl)	piperazino	2300
25	NEt₂	piperazino	1700
26	NH–CH₂C≡CH	piperazino	300
27	NH–CH₂Ph	piperazino	400
28	NH–CH₂(2-thienyl)	piperazino	300
29	NH–CH₂(2-thiazolyl)	piperazino	60
30	NH(CH₂-c-Pr)	homopiperazino	300
31	NH(CH₂-c-Pr)	N-Me-piperazino	1500
32	NH(CH₂-c-Pr)	morpholino	>7000
33	NH(CH₂-c-Pr)	4-(NH₂CH₂)-piperidino	70
34	NH(CH₂-c-Pr)	4-(NH₂)-piperidino	200
35	NH(CH₂-c-Pr)	4-piperidinyl-NH	710

See Table 1.

Inhibition of recombinant human KHK-C; >7000 nM relates to <50% inhibition at 7 μM.

Table 2. Structures and KHK Inhibition Results for Analogues of 3 with Variation of R2 and R3.