Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| compd | R2 | N-R3 | IC50 (nM)a |
|---|---|---|---|
| 8 | CH2-c-Pr | piperazino | 400 |
| 38 | CH2CH2OMe | piperazino | 140 |
| 40 | CH2(2-thiazolyl) | piperazino | 270 |
| 41 | CH2(2-pyridyl) | piperazino | 270 |
| 42 | H | piperazino | 78 |
| 46 | CH2-c-Pr | 3-(NH2CH2)-azetidino | 590 |
| 47 | CH2-c-Pr | 2,6-diazaspiro[3.3]hept-2-yl | 360 |
| 3b | CH2-c-Pr | piperazino | 2400 |
Inhibition of F1P production in HepG2 cell lysates. Number of experiments (n) and standard deviations are given in the Supporting Information.
The SMe in 8 is replaced by Me.
