Table 1. Comparison of (S)-9b and (S)-11b.

	(S)-9b	(S)-11b
Ki (hCRTH2) (nM)	13	15
eosinophil chemotaxis IC50 (nM)	62	7.4
hWB assay IC50 (nM)	1800	69
Fu (h, r, m, %)	<1%/ ND/ND	2.3/3.0/6.3
Caco-2 permeation Papp (cm/s)	1.8 × 10–6	0.2 × 10–6
clearance in rat (L/kg/h)	0.72	0.15
oral bioavailability in rat (Fz, %)	5	6