Table 2. Comparison of (S)-17a and (S)-11b.

	(S)-17a	(S)-11b
Ki (hCRTH2) (nM)	35	15
eosinophil chemotaxis IC50 (nM)	47	7.4
hWB assay IC50 (nM)	150	69
Fu (h, r, m, %)	2.0/1.9/5.0	2.3/3.0/6.3
Caco-2 permeation Papp (cm/s)	0.6	0.2 × 10–6
clearance in mouse (L/kg/h)	0.8	0.8
oral bioavailability in mouse (Fz, %)	39	9
AUC po (5 mg/kg) (h ng/mL)	2400	580