. 2014 Apr 2;57(9):3803–3817. doi: 10.1021/jm500146g

Table 2. MRC and GI₅₀ Values for the Substitutions of Indoline Aromatic Ring.

graphic file with name jm-2014-00146g_0007.jpg

entry	compd	R₁	R₂	R₃	R₄	amox/clav^a^,^b	cefazolin^a^,^b	meropenem^a^,^c	GI₅₀^d
1	1	H	Br	H	H	4	4	4	17.1
2	6a	H	Cl	H	H	8	4	8	35
3	6b	H	Me	H	H	16	16	32	–
4	6c	H	MeO	H	H	>32	>32	>32	–
5	6d	H	F	H	H	16	16	16	–
6	6e	H	H	H	H	16	16	16	–
7	6f	H	H	phenylene		>32	>32	>32	–
8	6g	H	H	H	Br	>32	32	8	–
9	6h	H	H	Br	H	16	16	16	–
10	6i	Br	H	H	H	32	16	16	–
11	6j	H	Cl	H	F	16	16	32	–
12	6k	H	Cl	H	Cl	4	4	4	13.6
13	6l	H	Br	H	F	2	4	4	18.1

MRC values are in μg/mL.

MRSA ATCC BAA-44.

MRSA ATCC 33592.

HeLa cells; GI₅₀ values are in μg/mL.

Table 2. MRC and GI50 Values for the Substitutions of Indoline Aromatic Ring.