Table 3. MRC and GI₅₀ Values for 1 Analogues with Modifications on the Side Chain.

entry	compd	R1	R2	amox/clava,b	cefazolina,b	meropenema,c	GI50d
1	1	H	SO2PhpCl	4	4	4	17.1
2	11a	H	H	32	32	32	–
3	11b	F	H	>32	32	16	16.2
4	12a	H	TFA	>32	>32	32	–
5	12b	H	COBu	>32	>32	32	–
6	12c	H	COPhpCl	>32	>32	>32	–
7	12d	H	SO2Ph	8	8	16	–
8	12e	H	SO2PhpMe	>32	>32	>32	–
9	12f	H	SO2PhpF	>32	>32	>32	–
10	12g	H	SO2PhpBr	4	4	8	40
11	12h	H	SO2PhpI	4	4	32	33
12	12i	H	SO2Ph3,4Cl	4	2	4	12.8
13	12j	H	SO2Ph2,4Cl	8	>32	4	–
14	12k	H	SO2PhpCN	16	8	16	–
15	12l	H	SO2PhpNHAc	>32	>32	32	–
16	12m	H	SO25Py	32	32	32	–
17	12n	H	SO2PhpNO2	>32	>32	>32	–
18	12o	H	SO2PhpNH2	16	16	16	–
20	13a	F	SO2PhpOMe	8	4	8	49
21	13b	F	SO2PhpMe	4	4	4	22
22	13c	F	SO2PhpF	4	4	4	18.3
23	6l	F	SO2PhpCl	2	4	4	18.1
24	13d	F	SO2PhpBr	1	1	1	22
25	13e	F	SO2PhpI	4	2	4	19.6
26	13f	F	SO2Ph3,4Cl	4	4	4	31
27	13g	F	SO2PhpNHAc	32	32	16	32
28	13h	F	SO2PhpCN	8	4	4	17.0
29	13i	F	SO2PhpCF3	4	4	4	8.7

^aMRC values are in μg/mL.

^bMRSA ATCC BAA-44.

^cMRSA ATCC 33592.

^dHeLa cells; GI₅₀ values are in μg/mL.