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. 2011 Jun 7;2(8):603–607. doi: 10.1021/ml2000627

Scheme 1. General Synthesis for HA Inhibitors 7–28.

Scheme 1

Reagents and conditions: (a) 2-Fluorobenzoic acid, HATU, NEt3, DCM, room temperature. (b) Lawesson's reagent, toluene, refluxing. (c) NH2NH2·H2O, DMSO, 150 °C. (d) Pyridine, DMSO, microwave, 150 °C. (e) CuI, K3PO4, l-proline, microwave, DMSO, 80–120 °C.