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. 2011 Jun 7;2(8):603–607. doi: 10.1021/ml2000627

Scheme 2. Synthesis of Substituted Benzenesulfonamides 31–35 and 40.

Scheme 2

Reagents and conditions: (a) (1) NaNO2, HCl; (2) CuCl, AcOH, SO2. (b) NH3, DCM. (c) CuI, K3PO4, l-proline, microwave, DMSO, 120 °C. (d) Compound 5, K2CO3, DMSO, 50 °C, 43%. (e) SnCl2·H2O, EtOH, reflux, 99%. (f) CuCl2·2H2O, t-BuONO, DMF, 45 °C, 22%.