Table 1. Anti-Influenza Activities of Compounds 7–28.

compd ID	Ar	R	EC50 (CPE, μM) a	CC50 (μM) b	MLM CLh (mL/min/kg) c
1	salicylamide	H	0.030	>50	76.7
7	1H-indazol-3-yl	H	6.90	>100	45.2
8	quinazolin-2-yl	H	8.5	26.7	82.9
9	benzothiazol-2-yl	H	2.12	36.8	85.4
10	benzothiazol-2-yl	6-F	2.5	16.2	78.2
11	benzothiazol-2-yl	6-Cl	>50	4.2
12	pyridin-2-yl	H	4.43	>100	80.6
13	pyridin-2-yl	5-CF3	3.39	30.5
14	pyridin-2-yl	6-CF3	0.22	13.5	82.3
15	Ph	H	0.43	37	85.6
16	Ph	2-Cl	0.52	6.9
17	Ph	3-Cl	0.057	9.7	86.1
18	Ph	4-Cl	0.44	8.1
19	Ph	2-CF3	0.15	6.6
20	Ph	3-CF3	0.042	7.8	83.8
21	Ph	3-CF3, 5-Cl	0.044	6.7	49.8
22	Ph	3-Cl, 5-F	0.015	4.4	85.1
23	Ph	3-CF3, 4-Cl	0.018	2.8	62.4
24	Ph	3-CN	0.25	46.9	84
25	Ph	3-PhO	>100	6.0
26	Ph	3-CONH2	37.9	>100	43.0
27	Ph	3-SO2Me	0.93	>50	65.3
28	Ph	3-SO2NH2	0.21	>100	37.2

^aCompound concentration to inhibit 50% of the cytopathic effect based on OD measurement. Values are the average of ≥two determinations run in duplicate, SD ± 15%.

^bCompound concentration to inhibit 50% of MDCK cell growth relative to control.

^cIn vitro mouse liver microsome clearance calculated using the well-stirred model. See ref (15) for details.