Table 2. Anti-Influenza Activities of Sulfonamide Analogues and Their DMPK Profiles.

compd	R	EC50 (CPE, μM) a	CC50 (μM) b	IC50 (μM) c	HLM CLh (mL/min/kg) d	MLM CLh (mL/min/kg) b
31	3-F	0.089	55.0	0.58	7.2	42.3
32	3-Cl	0.044	8.4	0.23	12.1	51.8
33	3-CF3	1.36	19.5	2.91	5.1	39.6
34	2-Me	0.56	81.5	1.13	8.5	43.7
35	2-OMe	2.62	>100	4.16	10.0	66.4
40	2-Cl	0.086	71.2	0.25	8.4	42.5

^aCompound concentration to inhibit the cytopathic effect based on OD measurement. Values are means of three determinations run in duplicate, SD ± 15%.

^bSee the notes in Table 1.

^cHalf maximal inhibition concentration to prevent hemolysis of chicken RBCs; values are the average of two duplicate experiments, SD ± 20%.

^dIn vitro human liver microsome clearance calculated using the well-stirred model.