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. 2010 Dec 29;2(2):107–112. doi: 10.1021/ml100306h

Figure 3.

Figure 3

In vivo characterization of 5d. (a) 5d dosed orally reduces blood lymphocyte counts in female Lewis rats 24 h postdose (N = 5/group; bars represent average blood lymphocyte counts + SE; circles represent average plasma concentration ± SE; *P < 0.05 vs vehicle by ANOVA/Dunnett’s Multiple Comparison Test). (b) Efficacy of 5d dosed orally at 2 and 20 μg/rat/day (approximately 0.01 and 0.1 mg/kg, respectively) in delaying onset and reducing disease score in an experimental autoimmune encephalomyelitis (EAE) model in female Lewis rats (N = 15/group; *P < 0.05 vs vehicle by Wilcoxon exact 2-sided test). Vehicle = 20% captisol, pH 2.