Table 3. Pharmacokinetic Parameters for 5d.
| species | Cl (L/(h kg)) | Vss (L/kg) | T1/2 (h) | MRT (h) | % F |
|---|---|---|---|---|---|
| rata | 0.18 | 1.8 | 5.9 | 10 | 64 |
| canineb | 0.071 | 1.2 | 38 | 17 | 41 |
| NHPc | 0.50 | 2.3 | 24 | 4.7 | 34 |
a
Male Sprague−Dawley (iv: 1 mg/kg, DMSO, N = 3; po: 2 mg/kg, 20% captisol pH 4.0, N = 2).
b
Male beagle (iv: 1 mg/kg, 20% captisol pH 4.0, N = 3; po: 1 mg/kg, 20% captisol/1% pluronic F68/1% HPMC pH 2.1, N = 3).
c
NHP = nonhuman primate, male cynomolgus (iv: 1 mg/kg, 20% captisol pH 4.0, N = 3; po: 1 mg/kg, 20% captisol/1% pluronic F68/1% HPMC pH 2.1, N = 3).