Table 2. In Vitro Profile of 20.

MW, PSA, cLogP	446, 112, 1.94
CHI LogD at pH 2.0, 7.4, and 10.5	1.25, 1.72, 1.41
solubility (FeSSIF, mg/mL)	0.16
permeability (MDCK type 2, nm/s)	200
hepatocyte CLi (mg/min/g liver; rat, dog, mouse, human)	<0.85, <1.70, <0.85, <0.85
CYP IC50 (μM, 1A2, 2C9, 2C19, 2D6, 3A4VG, 3A4 VR, n = 4)	>50, >50, >50, >50, >50, 29 ± 15