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Design of arylpiperazine bivalent ligands 3–5. The elements in red are the pharmacophoric groups, which allow the arylpiperazine moiety (anchor) to interact with the 5-HT3R binding site; magenta indicates the probe responsible for the interaction with a biological target (biofunctional probe, MPQC and Tacrine) or for a particular chemical property (chemofunctional probe, UAA); blue indicates the spacer.
