Table 1. cLogP and Observed PK Parameters for Compounds 5, 6, 3, and 7.
| compd no. | cLogP | predicted rat CL (L/h/kg) | rat CL (L/h/kg) | rat Vss (L/kg) | rat MRT (h) |
|---|---|---|---|---|---|
| 5 | 2.8 | <0.34 | 0.9 | 0.9 | 0.9 |
| 6 | 3.8 | 0.46 | 0.2 | 1 | 4.9 |
| 3 | 4.7 | <0.34 | 0.3 | 2.3 | 6.9 |
| 7 | 6.0 | <0.34 | 0.4 | 4.3 | 11 |
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