Table 2. Human BRS-3 Binding and Functional Potency for Compounds 3−22.

compd	hBRS-3a IC50 (nM)	hBRS-3a EC50 (nM) (% act)b
3	16 ± 6	66 ± 16 (97 ± 4%)
7	82 ± 16	220 ± 22 (99 ± 4%)
14	17 ± 5	67 ± 13 (99 ± 2%)
15	5 ± 1	16 ± 3 (94 ± 5%)
21	11 ± 2	14 ± 4 (94 ± 6%)
22	27 ± 13	25 ± 3 (102 ± 6%)

^aData expressed as means ± SDs (≥3 independent experiments).

^b% act represents the maximum activation of tested compounds relative to that of dY peptide.