Table 3. Rat Plasma Clearance,^a Protein Binding,^b and Stability^c for Compounds 3−22.

	rat in vivo		rat microsomal incubation
compd	Clp (mL/min/kg)	plasma Fu (%)	T1/2 (min)	Fu (%)
3	12	ND	3	NDd
7	14	0.1	1	20
14	28	0.4	5	20
15	110	6.8	ND	ND
21	52	3.2	ND	ND
22	20	1.0	ND	ND

^aPlasma clearance (Cl_p) calculated following 1 mg/kg iv dose.

^bProtein binding assessed using human plasma (200 μL) or microsomal proteins (0.2 mg/mL) and test compound (1 μM).

^cMicrosomal stability assessed using liver microsomes (0.2 mg protein/mL) and test compound (1 μM).

^dNot determined.