. 2010 Oct 18;2(1):43–47. doi: 10.1021/ml100196d

Table 4. Dog Pharmacokinetic Data^a for Pyrazole Analogues 21 and 22.

compd	Cl_p (mL/min/kg)	T_1/2 (h)	po AUC_N [μM h/(mg/kg)]	F_oral (%)
21	10	0.3	1.4	29
22	5.6	1.4	3.7	52

Plasma clearance (Cl_p) and half-life (T_1/2) calculated following 0.5 mg/kg iv dose. Normalized oral exposure (po AUC_N) and oral bioavailability (F_oral) calculated following 1 mg/kg po dose.

Table 4. Dog Pharmacokinetic Dataa for Pyrazole Analogues 21 and 22.

Table 4. Dog Pharmacokinetic Data^a for Pyrazole Analogues 21 and 22.