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Representative members of the 2-deoxystreptamine aminoglycoside classes characterized by 4,6-disubstitution (amikacin and gentamicin C1) or 4,5-disubstitution (neomycin B). Arrows indicate positions targeted by modifying enzymes prevalent in S. aureus (black, complete resistance; gray, medium resistance; white and crossed, evaded). See Supporting Information file for complete tabulation of aminoglycoside antibiotic structures.
