Skip to main content
. 2011 Sep 29;2(12):924–928. doi: 10.1021/ml200202y

Scheme 1. Application of the Garegg–Samuelsson Modification of the Tipson–Cohen Reaction for Tetradeoxygenation in the Paromomycin and Neomycin Series.

Scheme 1

Reagents: (a) TBSOTf, 2,6-lutidine, DCM, 0 °C; (b) PPh3, imidazole, triiodoimidazole, toluene, MeCN, reflux; (c) HF·py, py; (d) H2, Pd(OH)2/C, AcOH/H2O (4:1); (e) TrCl, cat. DMAP, py, 70 °C; (f) H2, Pd(OH)2/C, 1 N HCl, MeOH.