Table 1. Minimum Inhibitory Concentration of Tetradeoxygenated Antibiotic Analogues and Controls (μg/mL)a.
| S. aureus strain | Amk | Gent | NeoB | Par | H-Par | Ribo | Btr | 4 | 9 | 7 | 1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ATCC 29213 | 4 | 0.5 | 0.5 | 2 | 2 | 8 | 8 | 2 | 1 | 0.5 | 0.5 |
| APH(3′/5″)-III | 8 | 0.5 | >64 | >64 | 32 | >64 | >32 | ND | ND | 32 | 1 |
| ANT(4′)-I | 64 | 0.5 | >64 | >64 | >64 | >64 | >32 | 4 | 8 | 0.5 | 1 |
| APH(2″)/AAC(6′) | 64 | >64 | >64 | >64 | >32 | >64 | >32 | >32 | 16 | >64 | 2 |
a
Abbreviations: Amk, amikacin; Gent, gentamicin C complex; NeoB, neomycin B; Par, paromomycin; H-Par, N1-HABA paromomycin; Ribo, ribostamycin; Btr, butirosin (N1-HABA ribostamycin); ATCC, American Type Colony Collection; APH, aminoglycoside phosphotransferase; ANT, aminoglycoside nucleotidyltransferase; AAC, aminoglycoside N-acetyltransferase; ND, not determined.