Table 2. In Vitro Clearance in Human and Rat Liver Microsomes and Human CYP Inhibition Data for Selected Compounds.

compd	Clint (HLM/RLM)a (μL/min/mg prot)	CYP inhibition (2C8/2C9/2C19) IC50 (μM)
16	>1000/43	0.32/0.84/0.26
29	1700/30	0.47/0.34/0.90
39	>1000/125	0.57/0.64/0.68
48	<10/<10	0.086/0.28/0.038
51	<10/12	0.043/0.20/0.051
55	55/10	0.97/2.0/3.7
58	<10/<10	0.054/>20/0.15
60	17/17	0.079/1.7/7.5
61	92/40	0.22/7.4/12
63	28/20	0.050/0.29/0.17

^aHLM, human liver microsomes; RLM, rat liver microsomes.