Table 2. Inhibition of CYP11B2 and CYP11B1 by Compounds 25−32.

		IC50 value (nM)a,b				IC50 value (nM)a,b
n	no.	CYP11B1	CYP11B2	sfc	no.	CYP11B1	CYP11B2	sfc
	25	5	30	5.9	26	75	677	9.0
0	27	3	11	3.4	30	>1000	>1000
1	28	4	8	2.0	31	>1000	>1000
2	29	80	290	3.6	32	>1000	>1000
MTPd		15	72	4.8
ETOd		0.5	0.1	0.2
KTZd		127	67	0.5

^aMean value of at least three experiments. The deviations were within <±25%.

^bHamster fibroblasts expressing human CYP11B1 or CYP11B2; substrate 11-deoxycorticosterone, 100 nM.

^csf: IC₅₀ (CYP11B2)/IC₅₀ (CYP11B1).

^dMTP, metyrapone; ETO, etomidate; and KTZ, ketoconazole.