Skip to main content
. 2010 Oct 22;2(1):2–6. doi: 10.1021/ml100071j

Table 3. Inhibition of CYP11B1, CYP11B2, CYP17, and CYP19 by Compounds 33−36.

graphic file with name ml-2010-00071j_0007.jpg

graphic file with name ml-2010-00071j_0008.jpg
a

Mean value of at least three experiments. The deviations were within <±25%.

b

Hamster fibroblasts expressing human CYP11B1 or CYP11B2; substrate 11-deoxycorticosterone, 100 nM.

c

sf: IC50 (CYP11B2)/IC50 (CYP11B1).

d

Described in ref (36).

e

MTP, metyrapone; ETO, etomidate; and KTZ, ketoconazole.

f

E. coli expressing human CYP17; substrate progesterone, 25 μM; inhibitor concentration, 2.0 μM.

g

Human placental CYP19; substrate androstenedione, 500 nM; inhibitor concentration, 500 nM.