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Reagents and conditions: (a) n-Butyllithium, THF, −78 °C. (b) (1) 2 N HCl, H2O, THF; (2) Na2CO3, pH 8. (c) LDA, THF, −78 °C, 21, 20% yield for 24, 25% yield for 26. (d) H2, Pd/C, Et3N, MeOH. (e) Lithium 2,2,6,6-tetramethylpiperidinide, THF, −78 °C, 21, 12% yield for 28a, 10% yield for 28b.
