Figure 1.

Characteristics of cMLV (Dox+PTX). (A–C) The hydrodynamic size distribution of cMLV(Dox), cMLV(PTX), and cMLV(Dox+PTX) measured by dynamic light scattering. The mean hydrodynamic diameter (HD) and polydispersity index (PI) of cMLV(Dox), cMLV(PTX), and cMLV(Dox+PTX) are indicated on the graph. (D, E) Effects of coencapsulation of Dox and PTX on loading capability and drug release kinetic profiles of cMLVs. The encapsulation efficiency (D) and loading efficacy (E) of drugs in cMLV(combined drugs) and cMLV (single drug). (F–H) In vitro release kinetics of doxorubicin and paclitaxel from dual-drug loaded cMLVs and single-drug loaded cMLVs. Error bars represent the standard deviation of the mean from triplicate experiments.