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. 2014 Mar 27;11(5):1651–1661. doi: 10.1021/mp5000373

Figure 3.

Figure 3

Drug ratio-dependent efficacy of cMLV(Dox+PTX) in tumor treatment. (A) Tumor growth was measured after treatment with PBS, 3.33 mg/kg Dox + 0.67 mg/kg PTX, 2 mg/kg Dox + 2 mg/kg PTX, 0.67 mg/kg Dox + 3.33 mg/kg PTX, either in cMLVs or in solution every 3 days. Tumor growth and body weights were monitored until the end of the experiment. Error bars represent standard error of the mean, n = 6 for each treatment group (*p < 0.05, **p < 0.01). (B) Average mouse weight loss over the duration of the experiment. (C) Survival curves for 4T1 bearing mice treated with PBS, 3.33 mg/kg Dox + 0.67 mg/kg PTX, 2 mg/kg Dox + 2 mg/kg PTX, 0.67 mg/kg Dox + 3.33 mg/kg PTX either in cMLVs or in solution every 3 days. The survival rates are presented as Kaplan–Meier curves. The survival curves of individual groups were compared by a log-rank test.