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In vivo maintenance of Dox–PTX ratios in cMLV formulations. (A, B) Tumor-bearing mice were treated with PBS, 8.333 mg/kg Dox + 1.667 mg/kg PTX, 5 mg/kg Dox + 5 mg/kg PTX, or 1.667 mg/kg Dox + 8.33 mg/kg PTX, either in cMLVs (A) or in solution (B). Twenty-four h after injection, tumors were excised, and drug concentrations of Dox and PTX were measured by HPLC. All data are shown as the means of triplicate experiments.
