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. 2011 Mar 31;2(6):481–484. doi: 10.1021/ml200053x

Scheme 1. General Synthesis of 2-Chlorpyridine Benzanildes.

Scheme 1

Reagents and conditions: (a) Nucleophile, MeOH. (b) Pd/C 10% H2, DCM. (c) DPPA, TEA, t-butanol. (d) TFA, DCM. (e) (CO)2Cl2, DCM, DMF (cat) 0° to room temperature. (f) DIEA, DCM, room temperature.