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. 2011 Mar 31;2(6):481–484. doi: 10.1021/ml200053x

Table 1. KCNQ2/Q3 Activity of N-(6-Substituted Pyridin-3-yl)-3,4-diflourobenzamide.

graphic file with name ml-2011-00053x_0004.jpg

compd no. Y-substituent KCNQ2/Q3 EC50 (μM)
5 F 4.8
6 CH3 6.8
7 SCH3 >10
8 CF3 >10
9 CN 10
10 OH >10
11 OCH3 >10
12 Cl 0.38
13 NH-cyclopropyl 2.7
14 1-pyrrolidine 0.48
15 1-morpholine 7.8