Table 1. KCNQ2/Q3 Activity of N-(6-Substituted Pyridin-3-yl)-3,4-diflourobenzamide.
compd no. | Y-substituent | KCNQ2/Q3 EC50 (μM) |
---|---|---|
5 | F | 4.8 |
6 | CH3 | 6.8 |
7 | SCH3 | >10 |
8 | CF3 | >10 |
9 | CN | 10 |
10 | OH | >10 |
11 | OCH3 | >10 |
12 | Cl | 0.38 |
13 | NH-cyclopropyl | 2.7 |
14 | 1-pyrrolidine | 0.48 |
15 | 1-morpholine | 7.8 |