Table 2. KCNQ2/Q3 and KCNQ1 Activity of N-(6-Chloropyridin-3-yl) Benzamides^a.

compd no.	R-substituent	KCNQ2/Q3 EC50 (μM)	KCNQ1 IC50 (μM)
12	3,4-F2	0.38	41
16	4-Cl	0.38	15
17	H	1.6	>100
18	2-F	>10	NT
19	3-F	1.1	77
20	4-F	0.98	66
21	3-CF3	0.39	5.8
22	4-CF3	0.32	2.9
23	4-Ph	0.26	>30
24	3-OCH3	5.5	NT
25	3,4 (CH3)2	0.69	>100
26	3,4-Cl2	0.67	17
27	3-Cl	0.27	41
28	3-F, 4-Cl	0.08	15
29	3-CF3, 4-F	0.42	3.4
30	4-SO2NH2	>10	NT
31	3-F, 4-CF3	0.37	3.4
32	3-Cl, 4-F	0.19	22
33	3-F, 4-CH3	0.28	33
34	3-CN	>10	NT
35	2,3-F2	>10	NT
36	4-OC6H5	0.01	1.9
37	3-F, 4-CN	1.1	51
38	3-F, 4-OCH3	3.2	>100
39	3-F, 4-OEt	0.57	>100
40	3-F, 4-OiPr	0.17	>100
41	3-F, 4-OC6H5	0.03	1.3
42	3-F, 4-(4F−C6H5S)	0.08	>100
43	3-F, 4-(4F−C6H5SO2)	0.07	>100
44	3-F, 4-(4F−C6H5CH2S)	1.6	>100
45	3-F, 4-(4F−C6H5CH2SO2)	0.16	>100
46	3-F, 4-SiPr	0.11	5.8
47	3-F, 4-SiBu	0.14	>100
48	3-F, 4-SO2iBu	0.26	54
49	3-F, 4-NHCH2CH2C6H5	0.18	>100

^aNT, not tested.