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| compd no. | R1 | KCNQ2/Q3 EC50(μM) | KCNQ3/Q5 EC50 (μM) | KCNQ1 IC50 (μM) |
|---|---|---|---|---|
| 50 | 3-F | 7.2 | 23 | >100 |
| 51 | 3,4-F2 | 0.69 | 14.3 | >100 |
| 52 | 3-Cl | 1.1 | 14 | 78 |
| 53 | 3-CF3 | 4.3 | 28 | 35 |
| 54 | 3-F,4-Cl | 0.41 | 9 | 49 |
| 55 | 3-F,4-CH3 | 0.60 | 10 | 93 |
