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. 2011 Apr 4;2(7):494–497. doi: 10.1021/ml100302t

Figure 3.

Figure 3

Effects of NO scavengers on DOXO and NO−DOXOs accumulation and toxicities. HT29-dx cells were incubated in the absence (−) or presence (CTRL) of 5 μM DOXO, 4, or 5 for 24 h; when indicated, 100 μM PTIO (PT) or 10 μL/mL of packed red blood cells was coincubated. The intracellular drug content (A), the extracellular activity of LDH (B), and the nitrite amount in the culture supernatant (C) were measured in duplicate as described in the Supporting Information (n = 3). Significance for A: vs CTRL DOXO, *p < 0.002; vs DOXO or 4 or 5, °p < 0.05. For B and C: vs CTRL DOXO, *p < 0.05; vs DOXO or 4 or 5, °p < 0.05.