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| IC50 (nM) |
|||
|---|---|---|---|
| compd | R | ACHN | HT-29 |
| 4a | H | 10000 (1) | 1300 (1) |
| 4b | Me | 1300 (2) | 110 (2) |
| 4c | Et | 185 (3) | 27 (3) |
| 4d | Pr | 2100 (2) | 230 (2) |
| 4e | cPr | 290 (2) | 39 (2) |
| 4f | vinyl | 104 (3) | 15 (3) |
| 4g | C≡CH (ethynyl) | 42 (2) | 5.9 (2) |
| 4h | C≡C−Me | >3000 (1) | >1000 (1) |
| 4i | CN | >10000 (1) | 1600 (1) |
| 4j | F | >3000 (1) | >1000 (1) |
| 4k | Cl | 4600 (2) | 102 (2) |
| 4l | Br | 325 (4) | 15 (4) |
| 4m | I | 13 (2) | 1.5 (2) |
Numbers in parentheses represent numbers of determinations.
