Table 1.
Baseline Characteristics of MESA COPD Study Participants Stratified by Quartiles of Percent Predicted Residual Lung Volume.
| Characteristic | Quartiles of Percent Predicted Residual Volume | |||
|---|---|---|---|---|
| No. | 1.33 L N=29 | 1.73 L N=30 | 2.09 L N=30 | 2.89 L N=30 |
| Age - years | 69±5 | 69±6 | 69±8 | 68±6 |
| Male sex - no. (%) | 17 (59) | 16 (53) | 15 (50) | 18 (60) |
| Race or ethnic group - no. (%)† | ||||
| Caucasian | 19 (66) | 23 (77) | 24 (80) | 23 (77) |
| African American | 5 (17) | 4 (13) | 5 (17) | 7 (23) |
| Other | 5 (17) | 3 (10) | 1 (3) | 0 (0) |
| Height - cm | 169±11 | 168±9 | 167±10 | 169±9 |
| Weight - kg | 77±16 | 79±17 | 75±18 | 76±19 |
| Body-surface area - m2 | 1.9±0.2 | 1.9±0.2 | 1.9±0.3 | 1.9±0.3 |
| Cigarette smoking status - no. (%) | ||||
| Former smoker | 21 (72) | 18 (60) | 20 (67) | 15 (50) |
| Current smoker | 8 (28) | 12 (40) | 10 (33) | 15 (50) |
| Pack-years of smoking - no.† | ||||
| Median (IQR) | 36 (27) | 32 (26) | 40 (30) | 50 (34) |
| Blood pressure - mm Hg | ||||
| Systolic | 119±15 | 119±16 | 126±18 | 123±13 |
| Diastolic | 67±9 | 70±12 | 72±10 | 75±9 |
| Hypertension - no. (%) | 7 (24) | 12 (40) | 17 (57) | 16 (53) |
| Fasting plasma glucose - mg/dl | ||||
| Median (IQR) | 96 (19) | 104 (22) | 102 (20) | 98 (17) |
| Diabetes mellitus - no. (%) | 2 (7) | 4 (13) | 6 (20) | 6 (20) |
| Total Cholesterol - mg/dl | 183±36 | 197±45 | 187±41 | 178±37 |
| Lipid lowering med use - no. (%) | 15 (52) | 8 (27) | 15 (50) | 11 (37) |
| COPD - no. (%) | 13 (45) | 16 (53) | 21 (70) | 27 (90) |
| GOLD - COPD severity - no. (%) | ||||
| Mild | 9 (31) | 7 (23) | 11 (37) | 2 (7) |
| Moderate | 4 (14) | 9 (30) | 8 (27) | 13 (43) |
| Severe / very severe | 0 (0) | 0 (0) | 2 (7) | 12 (40) |
| Plethysmography: | ||||
| Residual volume - L | 1.33±0.30 | 1.73±0.31 | 2.09±0.35 | 2.89±0.64 |
| FRC - L | 2.94±0.75 | 2.99±0.67 | 3.41±0.71 | 4.04±0.80 |
| TLC - L | 5.28±1.27 | 5.48±1.18 | 5.69±1.21 | 6.14±1.14 |
| Residual volume to TLC ratio | 0.26±0.04 | 0.32±0.04 | 0.37±0.04 | 0.47±0.07 |
| Post-bronchodilator spirometry: | ||||
| FEV1 - L | 2.54±0.68 | 2.46±0.64 | 2.15±0.69 | 1.54±0.55 |
| FVC - L | 3.63±0.97 | 3.61±0.92 | 3.47±0.95 | 3.14±0.86 |
| FEV1 to FVC ratio | 0.70±0.07 | 0.69±0.09 | 0.62±0.12 | 0.50±0.12 |
| Percent emphysema−950 HU - median (IQR) | 1.2 (2.4) | 1.4 (2.4) | 1.7 (3.9) | 7.7 (16) |
| Left ventricle measures: | ||||
| Mass - grams | 122±29 | 131±39 | 129±34 | 131±35 |
| End-diastolic volume - ml | 121±26 | 116±26 | 114±23 | 112±36 |
| End-systolic volume - ml | 49±14 | 44±15 | 46±14 | 46±21 |
| Stroke volume - ml | 71±16 | 72±16 | 68±14 | 66±18 |
| Ejection fraction - % | 59±6 | 62±7 | 60±7 | 60±8 |
| Mass to end-diastolic volume ratio | 1.03±0.18 | 1.13±0.26 | 1.13±0.17 | 1.20±0.22 |
| Inferoseptal wall thickness - mm | 9.6±1.7 | 10±2.1 | 10±1.7 | 11±1.9 |
| Lateral wall thickness - mm | 7.9±1.4 | 8.8±1.9 | 8.9±1.4 | 8.8±1.5 |
Plus-minus values are means ± standard deviation.
†
Race or ethnic group, smoking status and pack-year history were self-reported.
Abbreviations: COPD denotes chronic obstructive pulmonary disease, GOLD Global Initiative for Chronic Obstructive Lung Disease, FRC functional residual capacity, TLC total lung capacity, FEV1 forced expired volume in the first second, FVC forced vital capacity and HU Hounsfield units.