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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Circulation. 2013 Mar 14;127(14):1503–1511e6. doi: 10.1161/CIRCULATIONAHA.113.001653

Table 2.

Mean Increment in Left Ventricle Mass According to Measures of Hyperinflation in the MESA COPD Study.

Left Ventricular Mass Quartiles of residual lung volume Mean increment in grams of LV mass per standard deviation increase in residual lung volume (95% CI) P Value
Mean residual volume - L 1.24 1.71 2.15 2.99
LV mass - grams 109 121 135 148 13 (7.8 to 19) <0.001
Predicted LV mass - grams
        Model 1 125 128 130 134 4.2 (0.2 to 8.2) 0.035
        Model 2 119 123 127 135 7.2 (2.2 to 12) 0.004
Left Ventricular Mass to End-Diastolic Volume Ratio Quartiles of residual lung volume Mean increment in LV mass to EDV ratio per standard deviation increase in residual lung volume (95% CI) P Value
Mean residual volume - L 1.24 1.71 2.15 2.99
LV mass to end-diastolic volume ratio 1.00 1.09 1.19 1.21 0.06 (0.02 to 0.10) 0.001
Predicted LV mass to end-diastolic volume ratio
        Model 1 1.06 1.10 1.13 1.20 0.06 (0.01 to 0.11) 0.016
        Model 2 1.03 1.07 1.11 1.18 0.07 (0.01 to 0.13) 0.021
Left Ventricular Mass Quartiles of residual volume to total lung capacity ratio Mean increment in grams of LV mass per standard deviation increase in residual volume to total lung capacity ratio (95% CI) P Value
Mean residual volume to total lung capacity ratio 0.25 0.32 0.38 0.48
LV mass - grams 124 126 136 127 2.4 (-3.4 to 8.3) 0.42
Predicted LV mass - grams
        Model 1 125 128 130 133 3.1 (-0.5 to 6.7) 0.087
        Model 2 119 124 128 134 5.9 (1.4 to 10) 0.009
Left Ventricular Mass to End-Diastolic Volume Ratio Quartiles of residual volume to total lung capacity ratio Mean increment in LV mass to EDV ratio per standard deviation increase in residual volume to total lung capacity ratio (95% CI) P Value
Mean residual volume to total lung capacity ratio 0.25 0.32 0.38 0.48
LV mass to end-diastolic volume ratio 1.03 1.13 1.15 1.17 0.05 (0.02 to 0.09) 0.005
Predicted LV mass to end-diastolic volume ratio
        Model 1 1.06 1.10 1.14 1.20 0.05 (0.02 to 0.09) 0.004
        Model 2 1.03 1.08 1.12 1.19 0.06 (0.01 to 0.12) 0.013

Model 1 adjusted for: age, gender, race-ethnicity, height and body size indexing term45.

Model 2 additionally adjusted for: systolic blood pressure, hypertension, diabetes, total cholesterol level, lipid lowering medication use, current smoking status, FEV1 and percent emphysema−950 HU.

Abbreviations: LV denotes left ventricle, CI confidence interval, EDV end-diastolic volume, HU Hounsfield units, and FEV1 forced expired volume in the first second.