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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Transl Neurosci. 2013 Mar 1;4(1):8–19. doi: 10.2478/s13380-013-0111-8

Figure 5.

Figure 5

Representative images of synaptophysin immunoreactivity in the hippocampus (A), dentate gyrus (DG; B), CA3 region (C) and CA1–2 region (D) of a 2-month-old APPSL/PS1ho KI mouse, and in the hippocampus (E), dentate gyrus (F), CA3 region (G) and CA1–2 region (H) of a 10-month-old APPSL/PS1ho KI mouse. The white arrows (E, F, G) indicate possible dystrophic neurites, which have high synaptophysin immunoreactivity. Note the specific loss of CA1–2 neurons in the 10-month-old mouse (E, H, insert H), as compared to the 2 month old mouse (A, D, insert H), and as indicated by the black arrows. The black rectangles indicate the areas where B–D and F–H correspond to in A and E, respectively. The scale bar represents 1400 µm in A and E, 448 µm in B–D and F–H, and 224 µm in the inserts of D and H.